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Core 04: Cellular Methylation Guard
CORE 0460 servings (60 capsules)
-38% Excess circulating homocysteine
4.91 (164 Clinical Reviews)

Core 04: Cellular Methylation Guard

Target: Epigenetic Methylation & DNA Integrity60 servings (60 capsules)
Clinical Benchmark: -38% Excess circulating homocysteine

Quatrefolic® 5-MTHF + Betaine TMG + Methyl-B12 for optimal methyl donor availability, neurotransmitter synthesis, and DNA methylation.

Primary Biological Actions:
  • Supplies active methyl donors for precise epigenetic gene silencing
  • Bypasses genetic MTHFR enzyme conversion bottlenecks
  • Protects vascular endothelium and cardiovascular tone
  • Supports neurotransmitter balance (dopamine, serotonin)
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Quatrefolic® (6S)-5-MTHF Glucosamine SaltBioactive 4th-generation folate bypassing MTHFR mutation
800 mcg
Trimethylglycine (TMG / Betaine Anhydrous)Universal methyl donor for liver and DNA transmethylation
500 mg
Methylcobalamin (Bioactive Vitamin B12)Essential cofactor for methionine synthase
1,000 mcg
Pyridoxal-5-Phosphate (Active Vitamin B6)Direct cofactor for homocysteine transsulfuration
25 mg
Verified Protocol Feedback164 Reviews

What Practitioners Report

4.91/ 5.00
Based on 164 verified protocol reviews
All reviews from confirmed purchasers
Showing 3 of 164
September 2026

Formulation transparency is the differentiator

Full milligram disclosure with a third-party COA for the exact lot in hand. That alone puts this ahead of most of what I see patients bring into consults.

Dr. Alan Whitfield, MD
Preventive Medicine, Seattle
4 months on protocol
August 2026

Clean label, no filler bloat

Liposomal delivery, no proprietary blends, no magnesium stearate. Exactly what I was looking for and the subscription pause actually works in one tap.

Dana K.
Quantified-self practitioner, Portland
3 months on protocol
July 2026

Solid science, premium price

The clinical rationale is sound and the lab work checks out. Priced above the category, though the dosing justifies it compared with cheaper under-dosed alternatives.

Robert M.
Retired Cardiologist, Naples
5 months on protocol
Common Questions

Most reported effects appear between weeks 2 and 6. Biomarker shifts (NAD+, CRP, HRV) typically precede subjective changes, which is why we publish clinical benchmarks rather than promises about how you will feel.

Core 04: Cellular Methylation Guard
Core 04: Cellular Methylation Guard
$41.60(Save 20%)